A banner announcing National Nurse Anesthetists Week, January 25-31, 2004, is prominently displayed at the entrance of the American Association of Nurse Anesthetists headquarters in Park Ridge, Ill. National Nurse Anesthetists Week was formally established in 2000 to educate the American public about the safe, high-quality anesthesia care that Certified Registered Nurse Anesthetists have been providing for more than a century. To request promotional materials for the fifth annual week-long event, email firstname.lastname@example.org or fax (847) 692-2051.
A theory of inhaled anesthetic action disruption of ligand diffusion chreodesA novel theory of inhalational anesthesia extends beyond earlier work the author, invoking the concept of chreodes. Chreodes are passages through water, occurring near a protein surface, that are organized amino acid side chains of varying lipophilic status. The theory accounts for the nonspecific, ubiquitous, and modest stereospecificity observed for inhalation anesthetics.
Keywords: Inhaled anesthetics, ligand diffusion, mechanism of action, protein landscape, water chreodes.
Version: 2003;71:422-428.Authors: Lemont B. Kier, PhD